A MODEL FOR THE MEMBRANE TOPOLOGY OF THE NS3 PROTEIN AS PREDICTED FROM THE SEQUENCE OF SEGMENT-10 OF EPIZOOTIC HEMORRHAGIC-DISEASE VIRUS SEROTYPE-1

被引：21

作者：

JENSEN, MJ ^{[1
]}

WILSON, WC ^{[1
]}

机构：

[1] USDA ARS,ARTHROPOD BORNE ANIM DIS RES LAB,LARAMIE,WY 82071

来源：

ARCHIVES OF VIROLOGY | 1995年 / 140卷 / 04期

关键词：

D O I：

10.1007/BF01309968

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Segment 10, encoding nonstructural proteins 3 (NS3) and 3a (NS3a) of epizootic haemorrhagic disease virus serotype 1 (EHDV-1) was sequenced. Computer motif recognition programs were used for interpretation of the sequence data to predict a structure for NS3. Integral membrane protein theories were then applied to produce a general topological model for the EHDV-1 NS3 protein. Homology was observed between EHDV-1 NS3 integral membrane motifs and those similarly observed in the cognate proteins of other orbiviruses.

引用

页码：799 / 805

页数：7

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