CHANGES IN REGIONAL BLOOD-FLOW DISTRIBUTION AND OXYGEN-SUPPLY DURING HYPOXIA IN CONSCIOUS RATS

被引：76
作者：
KUWAHIRA, I [1 ]
GONZALEZ, NC [1 ]
HEISLER, N [1 ]
PIIPER, J [1 ]
机构：
[1] MAX PLANCK INST EXPTL MED,PHYSIOL ABT,W-3400 GOTTINGEN,GERMANY
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 1993年 / 74卷 / 01期
关键词：
RADIOACTIVE MICROSPHERES; SYSTEMIC HEMODYNAMICS; PERIPHERAL CIRCULATION; ORGAN BLOOD FLOW; TOTAL PERIPHERAL RESISTANCE; ORGAN VASCULAR RESISTANCE; ARTERIAL BLOOD PRESSURE; HEART RATE; HYPOXEMIA; OXYGEN TRANSPORT; SPRAGUE-DAWLEY RATS;
D O I：
10.1152/jappl.1993.74.1.211
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The effects of acute hypoxia on central hemodynamics, regional blood flow, and regional oxygen supply (blood flow X arterial O2 concentration) were studied in conscious resting rats. Regional blood flow was determined by the radiolabeled microsphere technique. Blood pressure, heart rate, and aortic blood flow increased and total peripheral resistance decreased significantly during hypoxia. Blood flow to brain, respiratory muscles, and liver increased both in absolute value and as a fraction of the aortic blood flow. Fractional blood flow to the gastrointestinal tract, spleen, pancreas, skin, fat, and hindlimb bones decreased during hypoxia; blood flow decreased in absolute values only in stomach and fat. Oxygen supply to brain, respiratory muscles, and liver increased during hypoxia, whereas it decreased in the remaining organs investigated.
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收藏
页码：211 / 214
页数：4
相关论文
共 24 条
  • [1] EFFECT OF HYPOXIA ON REGIONAL DISTRIBUTION OF CARDIAC-OUTPUT IN DOG
    ADACHI, H
    STRAUSS, HW
    OCHI, H
    WAGNER, HN
    [J]. CIRCULATION RESEARCH, 1976, 39 (03) : 314 - 319
  • [2] BAKER HJ, 1979, LABAROTATORY RAT, V2, P257
  • [3] BERGER PJ, 1977, J EXP BIOL, V71, P111
  • [4] THE HYPOXIC VENTILATORY RESPONSE OF RATS WITH INCREASED BLOOD-OXYGEN AFFINITY
    BIRCHARD, GF
    TENNEY, SM
    [J]. RESPIRATION PHYSIOLOGY, 1986, 66 (02): : 225 - 233
  • [5] BREDLE D, 1989, CLIN ASPECTS O2 TRAN, P53
  • [6] LOCAL AND REFLEX FACTORS AFFECTING DISTRIBUTION OF PERIPHERAL BLOOD FLOW DURING ARTERIAL HYPOXIA IN RABBIT
    CHALMERS, JP
    KORNER, PI
    WHITE, SW
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1967, 192 (02): : 537 - &
  • [7] SYSTEMIC HEMODYNAMICS AFFECTING CARDIAC-OUTPUT DURING HYPOCAPNIC AND HYPERCAPNIC HYPOXIA
    DAVIDSON, D
    STALCUP, SA
    MELLINS, RB
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (04) : 1230 - 1236
  • [8] INTRACELLULAR PH REGULATION DURING PROLONGED HYPOXIA IN RATS
    GONZALEZ, NC
    CLANCY, RL
    [J]. RESPIRATION PHYSIOLOGY, 1986, 65 (03): : 331 - 339
  • [9] ACID-BASE REGULATION IN PROLONGED HYPOXIA - EFFECT OF INCREASED P-CO2
    GONZALEZ, NC
    CLANCY, RL
    [J]. RESPIRATION PHYSIOLOGY, 1986, 64 (02): : 213 - 227
  • [10] CIRCULATORY ADJUSTMENTS TO HYPOXIA
    HEISTAD, DD
    ABBOUD, FM
    [J]. CIRCULATION, 1980, 61 (03) : 463 - 470
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