THE STREPTOKINASE DOMAIN RESPONSIBLE FOR PLASMINOGEN BINDING

被引：23

作者：

RODRIGUEZ, P

FUENTES, D

MUNOZ, E

RIVERO, D

ORTA, D

ALBURQUERQUE, S

PEREZ, S

BESADA, V

HERRERA, L

机构：

[1] CTR GENET ENGN & BIOTECHNOL,DIV THROMBOYLT,HAVANA,CUBA

[2] CTR GENET ENGN & BIOTECHNOL,DIV PHYS CHEM,HAVANA,CUBA

来源：

FIBRINOLYSIS | 1994年 / 8卷 / 05期

关键词：

D O I：

10.1016/0268-9499(94)90016-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation.

引用

页码：276 / 285

页数：10

共 34 条

[1] CEREBROVASCULAR COMPLICATIONS OF STREPTOKINASE INFUSION [J].