EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN CYTOMEGALOVIRUS-INFECTED GLIAL-CELLS OF RETINAS FROM AIDS PATIENTS

被引：67

作者：

DIGHIERO, P

REUX, I

HAUW, JJ

FILLET, AM

COURTOIS, Y

GOUREAU, O

机构：

[1] ASSOC CLAUDE BERNARD,INSERM,U118,UNITE RECH GERONTOL,F-75016 PARIS,FRANCE

[2] ASSOC CLAUDE BERNARD,INSERM,U360,LAB NEUROPATHOL RAYMOND ESCOUROLLE,F-75013 PARIS,FRANCE

[3] UNIV HOSP LA PITIE SALPETRIERE,ASSOC CLAUDE BERNARD,VIROL LAB,F-75013 PARIS,FRANCE

[4] ASSOC CLAUDE BERNARD,INSERM,U360,SERV OPHTHALMOL,F-75013 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 01期

关键词：

NITRIC OXIDE SYNTHASE; RETINAL GLIAL CELL; AIDS; CYTOMEGALOVIRUS; RETINITIS;

D O I：

10.1016/0304-3940(94)90833-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The inducible isoform of nitric oxide synthase has been detected in cytomegalovirus (CMV)-infected retinas from acquired immunodeficiency syndrome (AIDS) patients by immunohistochemistry and NADPH-diaphorase staining. Subsequent immunohistochemistry using antibodies against CMV antigens and glial fibrillary acidic protein (GFAP) demonstrated that inducible NOS was localized in CMV-infected glial cells, particularly Muller cells. These findings indicate that inducible NOS is expressed in vivo in the human retina as a result of Viral infection, and suggest that high levels of NO production might be involved in CMV-induced retinitis.

引用

收藏

页码：31 / 34

页数：4

相关论文

共 18 条

[1] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER [J].

BREDT, DS ;

SNYDER, SH .

NEURON, 1992, 8 (01) :3-11

[2] EVIDENCE FOR AN ANTIVIRAL EFFECT OF NITRIC-OXIDE - INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION [J].

CROEN, KD .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2446-2452

[3]

DEGIROLAMI U, 1992, OCULAR PATHOLOGY PRO, V26, P200

[4]

EKSTROM P, 1988, INVEST OPHTH VIS SCI, V29, P1363

[5] REACTIVE ASTROCYTES EXPRESS NADPH DIAPHORASE INVIVO AFTER TRANSIENT ISCHEMIA [J].

ENDOH, M ;

MAIESE, K ;

PULSINELLI, WA ;

WAGNER, JA .

NEUROSCIENCE LETTERS, 1993, 154 (1-2) :125-128

[6] NITRIC-OXIDE SYNTHASES IN THE CARDIOVASCULAR-SYSTEM [J].

FORSTERMANN, U ;

POLLOCK, JS ;

NAKANE, M .

TRENDS IN CARDIOVASCULAR MEDICINE, 1993, 3 (03) :104-110

[7] INDUCTION OF CALCIUM-INDEPENDENT NITRIC-OXIDE SYNTHASE ACTIVITY IN PRIMARY RAT GLIAL CULTURES [J].

GALEA, E ;

FEINSTEIN, DL ;

REIS, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10945-10949

[8] MOLECULAR-CLONING AND EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE FROM HUMAN HEPATOCYTES [J].

GELLER, DA ;

LOWENSTEIN, CJ ;

SHAPIRO, RA ;

NUSSLER, AK ;

DISILVIO, M ;

WANG, SC ;

NAKAYAMA, DK ;

SIMMONS, RL ;

SNYDER, SH ;

BILLIAR, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3491-3495

[9] DIFFERENTIAL REGULATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE BY FIBROBLAST GROWTH-FACTORS AND TRANSFORMING GROWTH-FACTOR-BETA IN BOVINE RETINAL PIGMENTED EPITHELIAL-CELLS - INVERSE CORRELATION WITH CELLULAR PROLIFERATION [J].

GOUREAU, O ;

LEPOIVRE, M ;

BECQUET, F ;

COURTOIS, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4276-4280

[10] INVIVO EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTALLY INDUCED NEUROLOGIC DISEASES [J].

KOPROWSKI, H ;

ZHENG, YM ;

HEBERKATZ, E ;

FRASER, N ;

RORKE, L ;

FU, ZF ;

HANLON, C ;

DIETZSCHOLD, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :3024-3027