LOCALIZATION OF THE CYP2D-GENE LOCUS TO HUMAN CHROMOSOME-22Q13.1 BY POLYMERASE CHAIN-REACTION, INSITU HYBRIDIZATION, AND LINKAGE ANALYSIS

被引：53
作者：
GOUGH, AC [1 ]
SMITH, CAD [1 ]
HOWELL, SM [1 ]
WOLF, CR [1 ]
BRYANT, SP [1 ]
SPURR, NK [1 ]
机构：
[1] IMPERIAL CANC RES FUND,MOLEC PHARMACOL GRP,EDINBURGH EH8 9XD,SCOTLAND
来源：
GENOMICS | 1993年 / 15卷 / 02期
关键词：
D O I：
10.1006/geno.1993.1082
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Using a combination of somatic cell hybrids, in situ hybridization, and linkage mapping, we have been able to localize the cytochrome P450 CYP2D6 gene to chromosome 22 in the region q13.1. Linkage analysis, using locus-specific primers, showed a maximum sex-average lod score of 8.12 (θ = 0.00) between the marker pH130 (D22S64) and CYP2D6, of 6.92 (θ = 0.00) between the marker KI839 (D22S95) and CYP2D6, and of 4.80 (θ = 0.036) between the platelet-derived growth factor β subunit gene (PDGFB) and CYP2D6. © 1993 by Academic Press, Inc.
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页码：430 / 432
页数：3
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