RADIATION-INDUCED CROSSLINKING OF PYRIMIDINE OLIGONUCLEOTIDES

被引：7
|
作者：
DIZDAROGLU, M
SIMIC, MG
机构：
[1] NBS, Radiation Physics Div,, Gaithersburg, MD, USA, NBS, Radiation Physics Div, Gaithersburg, MD, USA
来源：
RADIATION PHYSICS AND CHEMISTRY | 1985年 / 26卷 / 03期
关键词：
CHEMICAL REACTIONS - Crosslinking - CHROMATOGRAPHIC ANALYSIS - MASS SPECTROMETERS - Applications - RADIATION CHEMISTRY - RADIATION EFFECTS;
D O I：
10.1016/0146-5724(85)90070-6
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Small oligonucleotides of thymine and cytosine form crosslinks on gamma irradiation in a N//2O-saturated aqueous solution. Products of crosslinking were separated and isolated by high-performance liquid chromatography and characterized by capillary gas chromatography-mass spectrometry. Quantitative measurements revealed that approximately 50% of primary water radicals account for the crosslinking. Mechanisms of product formation are presented.
引用
收藏
页码：309 / 316
页数：8
相关论文
共 50 条
12345