Regulation of Ras signal transduction during T cell development and activation

被引：0

作者：

Lapinski, Philip E. ^{[1
]}

King, Philip D. ^{[1
]}

机构：

[1] Univ Michigan, Med Sch, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 1卷 / 02期

基金：

美国国家卫生研究院;

关键词：

T cells; T cell development; T cell activation; T cell receptor; signal transduction; Ras; Ras GTPase-activating proteins; Ras guanine nucleotide exchange factors;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However, precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.

引用

页码：147 / 153

页数：7

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