HYPOTENSIVE ACTION AND INCREASED PLASMA-RENIN ACTIVITY BY CA2+ANTAGONIST (NIFEDIPINE) IN HYPERTENSIVE PATIENTS

被引：0
|
作者：
AOKI, K
YOSHIDA, T
KATO, S
TAZUMI, K
SATO, I
TAKIKAWA, K
HOTTA, K
机构：
[1] NAGOYA CITY UNIV, SCH MED,DEPT MED 2,MIZUHO KU, NAGOYA 467, JAPAN
[2] NAGOYA CITY UNIV, SCH MED,DEPT PHYSIOL 1,MIZUHO KU, NAGOYA 467, JAPAN
来源：
JAPANESE HEART JOURNAL | 1976年 / 17卷 / 04期
关键词：
BAY; RELEASE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The Ca2+ antagonistic coronary vasodilator, Nifedipine, was sublingually administered by a dose of 30 mg to 19 patients with hypertension. Blood pressure of patients with essential hypertension (n = 14) decreased from 177 .+-. 24 to 123 .+-. 13 mm Hg systolic and from 108 .+-. 12 to 80 .+-. 11 mm Hg diastolic (mean .+-. SD) (P < 0.01). Heart rate increased significantly from 73 .+-. 11 to 85 .+-. 10 beats/min (P < 0.01). Plasma renin activity (PRA) increased significantly from 0.73 .+-. 0.62 to 1.50 .+-. 1.02 ng/ml per h (P < 0.05). The same tendency was observed in malignant and renovascular hypertension. In primary aldosteronism (n = 2), blood pressure decreased but PRA did not increase. Hypotensive action and increased plasma renin activity by Ca2+ antagonist, Nifedipine, were clearly demonstrated in patients with hypertension.
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页码：479 / 484
页数：6
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