Association of protein tyrosine phosphatase non receptor type 22 (PTPN22) C1858T gene polymorphism with type 1 diabetes mellitus in Egyptian children cohort

Background: The protein tyrosine phosphatase non receptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors. Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases. Aim: To analyze a possible association between 1858 C/T SNP and T1DM in Egyptian cohort. Patients and methods: Patients with T1DM and healthy controls were genotyped for the 1858 C/T SNP in PTPN22 gene. Results: A non-significant association between PTPN22 1858 C/T SNP and T1DM was found. 1858T/T genotype was not observed more frequently in T1DM patients compared to control subjects. Conclusion: In concordance with previous data establishing PTPN22 1858 C/T SNP association with several autoimmune diseases, our findings deny further evidence that the PTPN22 gene may play an important role in the susceptibility to T1DM. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of The Egyptian Pediatric Association.