ANTIMALARIAL ACTIVITY IN-VITRO OF COCHLOSPERMUM-TINCTORIUM TUBERCLE EXTRACTS

被引：52
作者：
BENOIT, F
VALENTIN, A
PELISSIER, Y
MARION, C
MALLIE, M
BASTIDE, JM
机构：
[1] UFR SCI PHARMACEUT,IMMUNOL & PARASITOL LAB,F-34060 MONTPELLIER,FRANCE
[2] UFR SCI PHARMACEUT,FAC PHARM,PHARMACOGNOSIE LAB,F-34060 MONTPELLIER,FRANCE
[3] PHARM LOMOE,BANFORA,BURKINA FASO
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 02期
关键词：
PLASMODIUM FALCIPARUM; COCHLOSPERMUM TINCTORIUM; ANTIMALARIAL ACTIVITY IN VITRO;
D O I：
10.1016/0035-9203(95)90502-2
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Resistance of Plasmodium falciparum to current antimalarial compounds has drastically increased during the last few years and is now a major public health problem. We have studied plants traditionally used in Africa against malaria. Extracts of the tubercles of Cochlospermum tinctorium A. Rich, commonly used in Burkina Faso, were tested in vitro on 2 strains of P., falciparum, one (FcBl-Colombia) chloroquine resistant and the other (F32-Tanzania) chloroquine sensitive. Extracts were obtained by infusion and decoction. The 50% inhibitory concentrations (IC50) were determined by measuring [H-3]hypoxanthine incorporation and also by microscopical examination which permitted the determination of parasite stages. We obtained similar results with fresh extracts, frozen extracts, and lyophilized extracts of C. tinctorum. IC50 values were of the order of 1-2 mu g/mL, about one-tenth of those reported for extracts of neem leaves (Azadirachta indica) and about half the values reported for Artemisia annua extracts.
引用
收藏
页码：217 / 218
页数：2
相关论文
共 50 条
[41]   Chemical investigation and in vitro antimalarial activity of Tabebuia ochracea ssp neochrysantha [J].
Perez, H ;
Diaz, F ;
Medina, JD .
INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1997, 35 (04) :227-231
[42]   In vitro antimalarial activity and molecular modeling studies of novel artemisinin derivatives [J].
Gaur, Rashmi ;
Cheema, Harveer Singh ;
Kumar, Yogesh ;
Singh, Suriya Pratap ;
Yadav, Dharmendra K. ;
Darokar, Mahendra Padurang ;
Khan, Feroz ;
Bhakuni, Rajendra Singh .
RSC ADVANCES, 2015, 5 (59) :47959-47974
[43]   In vitro antimalarial activity of limonoids from Khaya grandifoliola CDC (Meliaceae) [J].
Bickii, J ;
Njifutie, N ;
Foyere, JA ;
Basco, LK ;
Ringwald, P .
JOURNAL OF ETHNOPHARMACOLOGY, 2000, 69 (01) :27-33
[44]   Carbon nanospheres conjugated bisphosphonates: synthesis, characterization and in vitro antimalarial activity [J].
Dlamini, N. L. ;
Mukaya, H. E. ;
Van Zyl, R. L. ;
van Vuuren, N. C. Jansen ;
Mbianda, X. Y. .
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 46 :S287-S296
[45]   Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates [J].
Kumar, Nitin ;
Khan, Shabana I. ;
Atheaya, Himanshu ;
Mamgain, Ritu ;
Rawat, Diwan S. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (07) :2816-2827
[46]   Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity [J].
Khanye, Setshaba D. ;
Smith, Gregory S. ;
Lategan, Carmen ;
Smith, Peter J. ;
Gut, Jiri ;
Rosenthal, Philip J. ;
Chibale, Kelly .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2010, 104 (10) :1079-1083
[47]   Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate [J].
Pintao, Ana Maria ;
Santos, Tiago ;
Nogueira, Fatima .
MOLECULES, 2024, 29 (10)
[48]   In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae) [J].
da Silva, Nazare Carneiro ;
Goncalves, Suellen Ferreira ;
de Araujo, Luciana Silva ;
Munchen Kasper, Aline Aparecida ;
da Fonseca, Amanda Luisa ;
Sartoratto, Adilson ;
Ferreira Castro, Kelly Christina ;
Pires Moraes, Tania Mara ;
Baratto, Leopoldo Clemente ;
Varotti, Fernando de Pilla ;
Soares Barata, Lauro Euclides ;
Moraes, Waldiney Pires .
ACTA AMAZONICA, 2019, 49 (04) :334-342
[49]   In-vitro antimalarial activities of Withania somnifera, Gymnema sylvestre, Ocimum gratisimum and Cajanus cajan. [J].
Morenikeji, O. A. ;
Pillai, C. R. ;
Valecha, N. ;
Dash, A. P. .
XII INTERNATIONAL CONGRESS OF PARASITOLOGY (ICOPA), 2010, :175-180
[50]   Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds [J].
Biot, C ;
Delhaes, L ;
N'Diaye, CM ;
Maciejewski, LA ;
Camus, D ;
Dive, D ;
Brocard, JS .
BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (12) :2843-2847
12345