PHENYLGLYCINE DERIVATIVES AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS

被引：314
|
作者：
WATKINS, J [1 ]
COLLINGRIDGE, G [1 ]
机构：
[1] UNIV BIRMINGHAM,SCH MED,DEPT PHARMACOL,BIRMINGHAM B15 2TT,ENGLAND
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 09期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0165-6147(94)90028-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Metabotropic glutamate receptors represent a family of G protein-coupled receptors that can be activated by L-glutamate, the principal excitatory neurotransmitter in the brain. Until recently, progress in identifying the physiological and pathological roles of metabotropic glutamate receptors has been hampered by the lack of selective antagonists. In this article, Jeff Watkins and Graham Collingridge describe the pharmacology of, and initial physiological studies using, certain phenylglycine derivatives and related substances-the first definitive antagonists of metabotropic glutamate receptors.
引用
收藏
页码：333 / 342
页数：10
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