ACTIVITY OF AZITHROMYCIN (CP-62,993) AND ERYTHROMYCIN AGAINST CHLOROQUINE-SENSITIVE AND CHLOROQUINE-RESISTANT STRAINS OF PLASMODIUM-FALCIPARUM INVITRO

被引：46

作者：

GINGRAS, BA ^{[1
]}

JENSEN, JB ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT MICROBIOL, E LANSING, MI 48824 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 47卷 / 03期

关键词：

D O I：

10.4269/ajtmh.1992.47.378

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Several antibiotics, including the macrolide erythromycin and the azalides azithromycin (CP-62,993) and CP-63,956, that inhibit protein synthesis on 70S ribosomes demonstrated antimalarial effects in vitro against two strains of Plasmodium falciparum, one sensitive to chloroquine and the other resistant. In 48-hr incubations, erythromycin was 10-fold less potent than the azalides against the chloroquine-resistant strain. Erythromycin and the azalides were essentially equipotent against the chloroquine-sensitive strain. An additive effect occurred with the azalides in combination with chloroquine against both strains, but this was not seen with erythromycin.

引用

页码：378 / 382

页数：5

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