INTRAVENOUS TRIGLYCERIDES FAIL TO ELICIT SATIETY IN SHAM-FEEDING RATS

被引：21
作者：
GREENBERG, D [1 ]
SMITH, GP [1 ]
GIBBS, J [1 ]
机构：
[1] CORNELL UNIV, COLL MED, DEPT PSYCHIAT, WHITE PLAINS, NY 10605 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 02期
关键词：
FATS; LIPIDS; FOOD INTAKE; CHOLECYSTOKININ; GASTROINTESTINAL CHEMORECEPTION;
D O I：
10.1152/ajpregu.1993.264.2.R409
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The satiating effect of intravenous fat infusions was investigated in sham-feeding rats. Intralipid infusions at loads of 2.5-10.0 kcal were administered into either the inferior vena cava or the hepatic-portal vein during sham feeding. Intravenous infusions of Intralipid by either route had no effect on sham feeding during 60-min tests. In earlier work we found that duodenal infusions of Intralipid rapidly inhibited sham feeding and elicited behaviors typical of satiety under test conditions identical to those of the present study. The lack of effect of intravenous infusions of Intralipid on sham feeding is further evidence for a preabsorptive site of action for t.he satiety effect of Intralipid.
引用
收藏
页码：R409 / R413
页数：5
相关论文
共 30 条
[1]   INTESTINAL SATIETY REQUIRES PRE-GASTRIC FOOD STIMULATION [J].
ANTIN, J ;
GIBBS, J ;
SMITH, GP .
PHYSIOLOGY & BEHAVIOR, 1977, 18 (03) :421-425
[2]   EFFECT OF VARIOUS TRIGLYCERIDES ON PLASMA CHOLECYSTOKININ LEVELS IN RATS [J].
DOUGLAS, BR ;
JANSEN, JBMJ ;
DEJONG, AJL ;
LAMERS, CBHW .
JOURNAL OF NUTRITION, 1990, 120 (07) :686-690
[3]   THE INFLUENCE OF DIFFERENT NUTRIENTS ON PLASMA CHOLECYSTOKININ LEVELS IN THE RAT [J].
DOUGLAS, BR ;
WOUTERSEN, RA ;
JANSEN, JBMJ ;
DEJONG, AJL ;
LAMERS, CBHW .
EXPERIENTIA, 1988, 44 (01) :21-23
[4]   ROLE OF CIRCULATING CHOLECYSTOKININ IN CONTROL OF FAT-INDUCED INHIBITION OF FOOD-INTAKE IN HUMANS [J].
DREWE, J ;
GADIENT, A ;
ROVATI, LC ;
BEGLINGER, C .
GASTROENTEROLOGY, 1992, 102 (05) :1654-1659
[5]   INCREASED APOLIPOPROTEIN-A-IV IN RAT MESENTERIC LYMPH AFTER LIPID MEAL ACTS AS A PHYSIOLOGICAL SIGNAL FOR SATIATION [J].
FUJIMOTO, K ;
CARDELLI, JA ;
TSO, P .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (06) :G1002-G1006
[6]   PLASMA SECRETIN, CCK, AND PANCREATIC-SECRETION IN RESPONSE TO DIETARY-FAT IN THE RAT [J].
GREEN, GM ;
TAGUCHI, S ;
FRIESTMAN, J ;
CHEY, WY ;
LIDDLE, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :G1016-G1021
[7]  
GREENBERG D, 1988, Society for Neuroscience Abstracts, V14, P1196
[8]   INTRADUODENAL INFUSIONS OF FATS ELICIT SATIETY IN SHAM-FEEDING RATS [J].
GREENBERG, D ;
SMITH, GP ;
GIBBS, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (01) :R110-R118
[9]  
GREENBERG D, 1989, ANN NY ACAD SCI, V575, P517
[10]   INFUSION OF CCK-8 INTO HEPATIC-PORTAL VEIN FAILS TO REDUCE FOOD-INTAKE IN RATS [J].
GREENBERG, D ;
SMITH, GP ;
GIBBS, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (05) :R1015-R1018
123