SOLID-PHASE EXTRACTION OF MIDAZOLAM AND 2 OF ITS METABOLITES FROM PLASMA FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS

被引：32

作者：

SAUTOU, V ^{[1
]}

CHOPINEAU, J ^{[1
]}

TERRISSE, MP ^{[1
]}

BASTIDE, P ^{[1
]}

机构：

[1] LAB PHARMACOL & PHARM CLIN & BIOTECH,UFR PHARM,PL HENRI DUNANT,F-63003 CLERMONT FERRAND,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 571卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80459-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid, sensitive and selective assay of midazolam and two of its metabolites in plasma, based on high-performance liquid chromatography, has been developed. The compounds are subjected to solid-phase extraction, using C18 cartridges (Bond-Elut). Recoveries are in excess of 90% for midazolam and its metabolites. The limit of quantitation of the assay is 50 ng/ml of plasma for each compound.

引用

页码：298 / 304

页数：7

共 19 条

[1] QUANTITATION BY GAS-CHROMATOGRAPHY OF THE 1-HYDROXY AND 4-HYDROXY METABOLITES OF MIDAZOLAM IN HUMAN-PLASMA [J].

ARENDT, RM ;

GREENBLATT, DJ ;

GARLAND, WA .

PHARMACOLOGY, 1984, 29 (03) :158-164

[2] INTRAVENOUS MIDAZOLAM FOR UPPER GASTROINTESTINAL ENDOSCOPY - A STUDY OF 800 CONSECUTIVE CASES RELATING DOSE TO AGE AND SEX OF PATIENT [J].

BELL, GD ;

SPICKETT, GP ;

REEVE, PA ;

MORDEN, A ;

LOGAN, RFA .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 23 (02) :241-243

[3] DETERMINATION OF MIDAZOLAM AND ITS MAJOR HYDROXY METABOLITE IN PLASMA BY GAS-LIQUID-CHROMATOGRAPHY - APPLICATION TO A PHARMACOKINETIC STUDY [J].

COASSOLO, P ;

AUBERT, C ;

SUMIRTAPURA, Y ;

CANO, JP .

JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1982, 5 (01) :31-37

[4] PLASMA-CONCENTRATIONS AND PHARMACOKINETICS OF MIDAZOLAM DURING ANESTHESIA [J].

CREVATPISANO, P ;

DRAGNA, S ;

GRANTHIL, C ;

COASSOLO, P ;

CANO, JP ;

FRANCOIS, G .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1986, 38 (08) :578-582

[5] THE DETERMINATION OF TOTAL AND UNBOUND MIDAZOLAM IN HUMAN PLASMA - A COMPARISON OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

DEVRIES, JX ;

RUDI, J ;

WALTERSACK, I ;

CONRADI, R .

BIOMEDICAL CHROMATOGRAPHY, 1990, 4 (01) :28-33

[6] WATER-SOLUBLE BENZODIAZEPINE, RO 21-3981, FOR INDUCTION OF ANESTHESIA [J].

FRAGEN, RJ ;

GAHL, F ;

CALDWELL, N .

ANESTHESIOLOGY, 1978, 49 (01) :41-43

[7] DETERMINATION OF CLIMAZOLAM IN THE PLASMA OF FARM-ANIMALS BY GAS-CHROMATOGRAPHY [J].

HEIZMANN, P ;

JORDAN, JC ;

LUDWIG, B .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 415 (01) :170-176

[8]

HEIZMANN P, 1981, Journal of High Resolution Chromatography and Chromatography Communications, V4, P266, DOI 10.1002/jhrc.1240040604

[9]

HELOL I, 1981, ARZNEIMITTEL-FORSCH, V31, P2284

[10]

KRAUS GB, 1988, ANAESTHESIST, V38, P658

← 1 2 →