HUMAN-COMPLEMENT FACTOR-B - FUNCTIONAL-PROPERTIES OF A RECOMBINANT ZYMOGEN OF THE ALTERNATIVE ACTIVATION PATHWAY CONVERTASE

被引：5

作者：

SCHWAEBLE, W

LUTTIG, B

SOKOLOWSKI, T

ESTALLER, C

WEISS, EH

ZUMBUSCHENFELDE, KHM

WHALEY, K

DIPPOLD, W

机构：

[1] UNIV HOSP MAINZ, MED CLIN 1, MAINZ, GERMANY

[2] UNIV MUNICH, INST IMMUNOL, W-8000 MUNICH 2, GERMANY

[3] LEICESTER ROYAL INFIRM, DEPT IMMUNOL, LEICESTER LE2 7LX, ENGLAND

来源：

IMMUNOBIOLOGY | 1993年 / 188卷 / 03期

关键词：

D O I：

10.1016/S0171-2985(11)80231-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human complement factor B is a centrally important component of the alternative pathway activation of the complement system. Here we report the isolation, characterization and eukaryotic expression of the first full length cDNA transcript for human factor B. In a factor B dependent haemolysis assay, the recombinant human factor B generated by transient COS cell transfection was shown to reconstitute haemolytic activity of factor B depleted human serum. To study the biological activities assigned to factor B, the availability of recombinant polypeptides representing definite portions of the human factor B molecule is desirable.

引用

页码：221 / 232

页数：12

共 31 条

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