THE INTERCONVERSION OF THE POLYMORPHIC FORMS OF CHLORAMPHENICOL PALMITATE (CAP) AS A FUNCTION OF ENVIRONMENTAL-TEMPERATURE

被引：15

作者：

DEVILLIERS, MM ^{[1
]}

VANDERWATT, JG ^{[1
]}

LOTTER, AP ^{[1
]}

机构：

[1] POTCHEFSTROOM UNIV CHRISTIAN HIGHER EDUC, IND PHARM RES INST, POTCHEFSTROOM 2520, SOUTH AFRICA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 10期

关键词：

D O I：

10.3109/03639049109057298

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

When polymorph B of chloramphenicol palmitate (CAP) is heated at 82-degrees-C for 1600 minutes it changes completely to the less soluble and less bioavailable polymorph A. When polymorph C, the most soluble polymorph, is grinded for a prolonged period it changes to polymorph A through B. We investigated the effect of the environmental temperature on the interconversion of polymorph C. This was done to determine the effect that heat generated during grinding could have on polymorph C. Samples of polymorph C was kept at 50 and 75-degrees-C respectively. At predetermined intervals samples were withdrawn and differential scanning colorimetric (DSC) curves and X-ray powder diffractograms recorded. Both samples changed to polymorph B but only the sample kept at 75-degrees-C changed into A during the time the experiment was run. Therefore temperature control during storage and handling, especially grinding, of polymorph C and B is recommended to prevent conversion to the poorly soluble and less bioavailable polymorph A.

引用

页码：1295 / 1303

页数：9

共 6 条

[1] EFFECT OF POLYMORPHISM ON ABSORPTION OF CHLORAMPHENICOL FROM CHLORAMPHENICOL PALMITATE [J].