N-(4-HYDROXY-4-METHYL-3-TETRAHYDROPYRANYL) DERIVATIVES OF AMINO-ACIDS - SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY

被引：0

作者：

KOVALEV, GV ^{[1
]}

VASILYEVA, SA ^{[1
]}

SAZHIN, VA ^{[1
]}

KULESHOVA, IP ^{[1
]}

BATALINA, IN ^{[1
]}

机构：

[1] BASHKIR STATE UNIV,UFA,RUSSIA

来源：

KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1991年 / 25卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nucleophilic substitution gave rise to N-(4-hydroxy-4-methyl-3-tetrahydropyranyl) derivatives of mono- and dicarboxylic neuroactive amino acids, followed by determination of the spectral and physicochemical characteristics of the compounds. Pyranyl derivatives of inhibitory amino acids such as glycine, beta-alanine, and gamma-aminobutyric acids were found to produce anticonvulsive and analgesic effects, lowering the emotional reaction of fear. N-(4-hydroxy-4-methyl-3-tetrahydropyranyl) derivatives of glutamic and aspartic acids prolonged the duration of tonic and clonic convulsations.

引用

页码：17 / 19

页数：3

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