SYNTHESIS OF THE C16-C23 EFFECTOR DOMAIN OF FK-506 VIA COPPER-CATALYZED METALATE REARRANGEMENT OF AN ALPHA-ALKOXYALKENYLCUPRATE

被引：0
作者：
JAROWICKI, K [1 ]
KOCIENSKI, P [1 ]
NORRIS, S [1 ]
OSHEA, M [1 ]
STOCKS, M [1 ]
机构：
[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND
来源：
SYNTHESIS-STUTTGART | 1995年 / 02期
关键词：
IMMUNOSUPPRESSANT; FK-506; EFFECTOR DOMAIN; 1,2-METALATE REARRANGEMENT; HIGHER ORDER CUPRATE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A 1,2-metallate rearrangement of the putative higher order cuprate 17 derived from reaction of the metallated dihydrofuran 15 with the homocuprate 16 occurred with clean inversion of configuration to give the alkenylcuprate 18. Methylation of 18 followed by Eve simple transformations completed the synthesis of the C16-C23 effector domain of the immunosuppressant FK-506.
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收藏
页码：195 / 198
页数：4
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