DIFFERENTIAL EXPRESSION OF BETA-AMYLOID PROTEIN-PRECURSOR (APP) AND TAU-MESSENGER RNA IN THE AGED HUMAN BRAIN - INDIVIDUAL VARIABILITY AND CORRELATION BETWEEN APP-751 AND 4-REPEAT TAU

被引：39

作者：

OYAMA, F

SHIMADA, H

OYAMA, R

TITANI, K

IHARA, Y

机构：

[1] UNIV TOKYO, FAC MED,INST BRAIN RES,DEPT NEUROPATHOL, 7-3-1 HONGO,BUNKYO KU, TOKYO 113, JAPAN

[2] FUJITA HLTH UNIV, INST COMPREHENS MED SCI, DIV BIOMED POLYMER SCI, TOYOAKE, AICHI 47011, JAPAN

[3] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT PATHOL, TOKYO, JAPAN

[4] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT NEUROPHYSIOL, ITABASHI KU, TOKYO 173, JAPAN

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 1991年 / 50卷 / 05期

关键词：

ALZHEIMERS DISEASE; AGED HUMAN; BETA-AMYLOID PROTEIN PRECURSOR; SPLICING; TAU;

D O I：

10.1097/00005072-199109000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the relationship between the differential expression of beta-amyloid protein precursor (APP) and tau mRNA, and the extent of beta and tau deposition in three regions from each of the 38 aged brains obtained from consecutive autopsied cases. Remarkable variabilities were noted in the ratios of APP-770/-751/ -695 and four-repeat tau among elderly individuals. There was no consistent alteration in the APP differential expression among beta-plaque (-), (+), and (++-+++) groups. Also, no differences in the four-repeat tau ratios were noted among tangle (-), (+), and (++) groups. Despite these great individual variabilities, APP-751 was found to be well-correlated with four-repeat tau. It is possible that APP-751 and four-repeat tau are increasing during aging, while APP-695 and three-repeat tau are decreasing.

引用

页码：560 / 578

页数：19