IMPORTANCE OF PHARMACOLOGICAL CONTROL IN PET STUDIES - EFFECTS OF THIOTHIXENE AND HALOPERIDOL ON CEREBRAL GLUCOSE-UTILIZATION IN CHRONIC-SCHIZOPHRENIA

被引：52
作者：
BARTLETT, EJ
WOLKIN, A
BRODIE, JD
LASKA, EM
WOLF, AP
SANFILIPO, M
机构：
[1] NYU MED CTR,DEPT PSYCHIAT,550 1ST AVE,NEW YORK,NY 10016
[2] NATHAN S KLINE INST PSYCHIAT RES,NEW YORK,NY
[3] VET ADM MED CTR,SERV PSYCHIAT,NEW YORK,NY 10010
[4] BROOKHAVEN NATL LAB,DEPT CHEM,CYCLOTRON PET PROGRAM,UPTON,NY 11973
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 1991年 / 40卷 / 02期
关键词：
POSITRON EMISSION TOMOGRAPHY; NEUROLEPTICS; DOPAMINE-D2; RECEPTORS; BASAL GANGLIA; FRONTAL LOBE; DEOXYGLUCOSE;
D O I：
10.1016/0925-4927(91)90003-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study compares the effects of two neuroleptic drugs with different pharmacologic characteristics (thiothixene and haloperidol) on cerebral glucose utilization in chronic schizophrenic inpatients. Positron emission tomographic (PET) scans were obtained from all subjects in a neuroleptic-free condition and again after 4-6 weeks of neuroleptic treatment. Eight subjects were treated with thiothixene and 12 with haloperidol. Thiothixene and haloperidol had different metabolic effects. For example, all thiothixene-treated subjects showed increased whole brain glucose utilization; all but one haloperidol-treated subject showed decreased utilization. Different patterns of relative prefrontal and striatal metabolism were also observed. These results highlight the importance of controlling for the effects of neuroleptic treatment and indicate the difficulty of interpreting data from studies with complex or poorly defined drug regimens.
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收藏
页码：115 / 124
页数：10
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