BASIC MECHANISMS OF TRAUMATIC BRAIN-DAMAGE

被引：140
作者：
SIESJO, BK
机构：
[1] Laboratory for Experimental Brain Research, University of Lund, Experimental Research Center, Lund
来源：
ANNALS OF EMERGENCY MEDICINE | 1993年 / 22卷 / 06期
基金：
美国国家卫生研究院;
关键词：
NEUROTRAUMA; BRAIN INJURY;
D O I：
10.1016/S0196-0644(05)82736-2
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Brain damage induced by blunt head trauma is multifactorial in that the initial injury both induces extensive depolarization and damages tissue through transient sheer forces that mechanically deform tissue components, especially axons and microvessels. Furthermore, although there is little evidence for initial energy depletion, subsequent tissue edema and microvascular perfusion shunting may result in areas of focal ischemia. This review suggests that these events lead to a final common pathway of neuronal death that involves loss of cellular calcium homeostasis, production of injurious free radicals, and tissue acidosis.
引用
收藏
页码：959 / 969
页数：11
相关论文
共 99 条
  • [71] Beckman, Beckman, Chen, Et al., Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc Natl Acad Sci USA, 87, pp. 1620-1624, (1990)
  • [72] Siesjo, Acidosis and ischemic brain damage, Neurochem Pathol, 9, pp. 31-88, (1988)
  • [73] Lundgren, Mans, Siesjo, Ischemia in normo- and hyperglycemic rats: Plasma energy substrates and hormones, Am J Physiol, 258, pp. E767-E774, (1990)
  • [74] Siesjo, Acid-base homeostasis in the brain: Physiology, chemistry, and neurochemical pathology, Progress in Brain Research, pp. 121-154, (1985)
  • [75] Chan, Longer, Fishman, Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema, Ann Neurol, 21, pp. 540-547, (1987)
  • [76] Cala, Volume regulation by red blood cells: Mechanisms of ion transport, Mol Physiol, 4, pp. 33-52, (1983)
  • [77] Kempski, Zimmer, Neu, Et al., Control of glial cell volume in anoxia. In vitro studies on ischemic cell swelling, Stroke, 18, pp. 623-628, (1987)
  • [78] Araki, Greenberg, Sladky, Et al., The effect of hyperglycemia on intracellular calcium in stroke, J Cereb Blood Flow Metab, 12, pp. 469-476, (1992)
  • [79] Rosner, Becker, Experimental brain injury: Successful therapy with the weak base, tromethamine, J Neurosurg, 60, pp. 961-971, (1984)
  • [80] Vink, Faden, McIntosh, Changes in cellular bioenergetic state following graded traumatic brain injury in rats: Determination by phosphorus 31 magnetic resonance spectroscopy, J Neurotrauma, 5, pp. 315-330, (1988)
12345678910