BASIC MECHANISMS OF TRAUMATIC BRAIN-DAMAGE

被引：140
作者：
SIESJO, BK
机构：
[1] Laboratory for Experimental Brain Research, University of Lund, Experimental Research Center, Lund
来源：
ANNALS OF EMERGENCY MEDICINE | 1993年 / 22卷 / 06期
基金：
美国国家卫生研究院;
关键词：
NEUROTRAUMA; BRAIN INJURY;
D O I：
10.1016/S0196-0644(05)82736-2
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Brain damage induced by blunt head trauma is multifactorial in that the initial injury both induces extensive depolarization and damages tissue through transient sheer forces that mechanically deform tissue components, especially axons and microvessels. Furthermore, although there is little evidence for initial energy depletion, subsequent tissue edema and microvascular perfusion shunting may result in areas of focal ischemia. This review suggests that these events lead to a final common pathway of neuronal death that involves loss of cellular calcium homeostasis, production of injurious free radicals, and tissue acidosis.
引用
收藏
页码：959 / 969
页数：11
相关论文
共 99 条
  • [91] Povlishock, Traumatically induced axonal injury: Pathogenesis and pathobiological implications, Brain Pathol, 2, pp. 1-12, (1992)
  • [92] Stokes, Fox, Hollinden, Extracellular calcium activity in the injured spinal cord, Exp Neurol, 80, pp. 561-572, (1983)
  • [93] Patt, Harken, Burton, Et al., Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains, J Clin Invest, 81, pp. 1556-1562, (1988)
  • [94] Cortez, McIntosh, Noble, Experimental fluid percussion brain injury: Vascular disruption and neuronal and glial alterations, Brain Res, 482, pp. 271-282, (1989)
  • [95] Eklof, MacMillan, Siesjo, The effect of hypercapnic acidosis upon the energy metabolism of the brain in arterial hypotension caused by bleeding, Acta Physiologica Scandinavica, 87, pp. 1-14, (1973)
  • [96] Siesjo, The role of calcium in cell death, Neurodoegenerative Disorders: Mechanisms and Prospects for Therapy, pp. 35-59, (1991)
  • [97] Seisjo, Cerebral circulation and metabolism, Journal of Neurosurgery, 60, pp. 883-908, (1984)
  • [98] Siesjo, Bengtsson, Grampp, Et al., Calcium excitotoxins and neuronal death in the brain, Annals of the New York Academy of Sciences, 568, pp. 234-251, (1989)
  • [99] Siesjo, Pathophysiology and treatment of focal cerebral ischemia II Mechanisms of damage and treatment, Journal of Neurosurgery, 77, pp. 337-354, (1992)
12345678910