New findings in osteoarthritis pathogenesis: therapeutic implications

被引:64
作者
Pulsatelli, Lia [2 ]
Addimanda, Olga [1 ]
Brusi, Veronica [1 ]
Pavloska, Branka [1 ]
Meliconi, Riccardo [1 ]
机构
[1] Rizzoli Orthopaed Inst, Lab Immunorheumatol & Tissue Regenerat, Rheumatol Unit, Via Barbiano 1-10, I-40136 Bologna, Italy
[2] Rizzoli Orthopaed Inst, Lab Immunorheumatol & Tissue Regenerat, RAMSES, Bologna, Italy
关键词
articular cartilage; new treatments; osteoarthritis; signaling pathways;
D O I
10.1177/2040622312462734
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review focuses on the new perspectives which can provide insight into the crucial pathways that drive cartilage-bone physiopathology. In particular, we discuss the critical signaling and effector molecules that can activate cellular and molecular processes in both cartilage and bone cells and which may be relevant in cross talk among joint compartments: growth factors (bone morphogenetic proteins and transforming growth factor), hypoxia-related factors, cell-matrix interactions [discoidin domain receptor 2 (DDR2) and syndecan 4], signaling molecules [WNT, Hedgehog (Hh)]. With the continuous progression of our knowledge on the molecular pathways involved in cartilage and bone changes in osteoarthritis (OA), an increasing number of potentially effective candidates for OA therapy are already under scrutiny in clinical trials to ascertain their possible safe use in an attempt to identify molecules active in slowing or halting OA progression and reducing joint pain. We then review the principal molecules currently under clinical investigation.
引用
收藏
页码:23 / 43
页数:21
相关论文
共 200 条
  • [1] The role of COX-2 produced by cartilage in arthritis
    Abramson, SB
    [J]. OSTEOARTHRITIS AND CARTILAGE, 1999, 7 (04) : 380 - 381
  • [2] Osteoarthritis and nitric oxide
    Abramson, Steven B.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2008, 16 : S15 - S20
  • [3] Aigner T, 2001, ARTHRITIS RHEUM-US, V44, P2777, DOI 10.1002/1529-0131(200112)44:12<2777::AID-ART465>3.0.CO
  • [4] 2-H
  • [5] Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Aigner, Thomas
    Fundel, Katrin
    Saas, Joachim
    Gebhard, Pia M.
    Haag, Jochen
    Weiss, Tilo
    Zien, Alexander
    Obermayr, Franz
    Zimmer, Ralf
    Bartnik, Eckart
    [J]. ARTHRITIS AND RHEUMATISM, 2006, 54 (11): : 3533 - 3544
  • [6] Unique and redundant roles of Smad3 in TGF-β-mediated regulation of long bone development in organ culture
    Alvarez, J
    Serra, R
    [J]. DEVELOPMENTAL DYNAMICS, 2004, 230 (04) : 685 - 699
  • [7] Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage:: Evidence for signaling via the EP4 receptor
    Attur, Mukundan
    Al-Mussawir, Hayf E.
    Patel, Jyoti
    Kitay, Alison
    Dave, Mandar
    Palmer, Glyn
    Pillinger, Michael H.
    Abramson, Steven B.
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (07) : 5082 - 5088
  • [8] Austin RC, 2009, ANTIOXID REDOX SIGN, V11, P2279, DOI 10.1089/ARS.2009.2686
  • [9] Erosive osteoarthritis of the hand: clinical experience with anakinra
    Bacconnier, L.
    Jorgensen, C.
    Fabre, S.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (06) : 1078 - 1079
  • [10] Induction of an Antiinflammatory Effect and Prevention of Cartilage Damage in Rat Knee Osteoarthritis by CF101 Treatment
    Bar-Yehuda, S.
    Rath-Wolfson, L.
    Del Valle, L.
    Ochaion, A.
    Cohen, S.
    Patoka, R.
    Zozulya, G.
    Barer, F.
    Atar, E.
    Pina-Oviedo, S.
    Perez-Liz, G.
    Castel, D.
    Fishman, P.
    [J]. ARTHRITIS AND RHEUMATISM, 2009, 60 (10): : 3061 - 3071