A PUTATIVE SERINE THREONINE PROTEIN-KINASE ENCODED BY THE SEGMENT-POLARITY FUSED GENE OF DROSOPHILA

被引：149

作者：

PREAT, T ^{[1
]}

THEROND, P ^{[1
]}

LAMOURISNARD, C ^{[1
]}

LIMBOURGBOUCHON, B ^{[1
]}

TRICOIRE, H ^{[1
]}

ERK, I ^{[1
]}

MARIOL, MC ^{[1
]}

BUSSON, D ^{[1
]}

机构：

[1] UNIV PIERRE & MARIE CURIE, PROPRE ASSOCIE LAB, CNRS, CTR GENET MOLEC, F-91198 GIF SUR YVETTE, FRANCE

来源：

NATURE | 1990年 / 347卷 / 6288期

关键词：

D O I：

10.1038/347087a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE segmented pattern of the Drosophila embryo depends on a regulatory cascade involving three main classes of genes1. An early regulatory programme, set up before cellularization, involves direct transcriptional regulation mediated by gap and pair-rule genes. In a second phase occurring after cellularization, interactions between segment-polarity genes are involved in cell communication2,3. Segment-polarity genes are required for pattern formation in different domains of each metamere and act to define and maintain positional information in each segment4. The segment-polarity gene fused is maternally required for correct patterning in the posterior part of each embryonic metamere1,5. It is also necessary later in development, as fused mutations lead to anomalies of adult cuticular structures and tumorous ovaries. Here we provide molecular evidence that this gene encodes a putative serine/threonine protein kinase, a new function for the product of a segmentation gene. This result provides further insight into segment-polarity interactions and their role in pattern formation. © 1990 Nature Publishing Group.

引用

页码：87 / 89

页数：3

共 42 条

[1]

ARIAS AM, 1988, DEVELOPMENT, V103, P157

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