Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes

被引：30

作者：

Derdemezis, Christos S. ^{[1
]}

Kiortsis, Dimitrios N. ^{[1
]}

Tsimihodimos, Vasilis ^{[2
]}

Petraki, Maria P. ^{[3
]}

Vezyraki, Patra ^{[1
]}

Elisaf, Moses S. ^{[2
]}

Tselepis, Alexandros D. ^{[3
]}

机构：

[1] Univ Ioannina, Sch Med, Lab Physiol, Ioannina 45110, Greece

[2] Univ Ioannina, Sch Med, Dept Internal Med, Ioannina 45110, Greece

[3] Univ Ioannina, Dept Chem, Ioannina 45110, Greece

来源：

BIOCHEMISTRY RESEARCH INTERNATIONAL | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/285618

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction. Adipose tissue contributes to atherosclerosis with mechanisms related to adipokine secretion. Polyphenols may exhibit antiatherogenic properties. The aim of the study was to investigate the effects of three polyphenols, namely, quercetin, epigallocatechin gallate (EGCG), and resveratrol on adipokine secretion from cultured human adipocytes. Methods. Human SGBS adipocytes were treated with quercetin, EGCG, and resveratrol for 24 and 48 hours. Visfatin, leptin, and adiponectin weremeasured in the supernatant. Results. Visfatin secretion was inhibited by quercetin 10 mu M by 16% and 24% at 24 and 48 hours respectively. The corresponding changes for quercetin 25 mu M were 47% and 48%. Resveratrol 25 mu M reduced visfatin by 28% and 38% at 24 and 48 hours. EGCG did not have an effect on visfatin. None of tested polyphenols influenced leptin and adiponectin secretion. Conclusion. Quercetin and resveratrol significantly decreased visfatin secretion from SGBS adipocytes. This effect may contribute to their overall antiatherogenic properties.

引用

页数：5

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