SYNTHESIS, CHEMICAL-PROPERTY, AND CYTOTOXICITY OF THE CARZINOPHILIN CONGENERS CARRYING A 2-(1-ACYLAMINO-1-ALKOXYCARBONYL)METHYLIDENE-1-AZABICYCLO[3.1.0]HEXANE SYSTEM

被引：40

作者：

HASHIMOTO, M ^{[1
]}

MATSUMOTO, M ^{[1
]}

YAMADA, K ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 14期

关键词：

CARZINOPHILIN CONGENERS; SYNTHESIS; CHEMICAL PROPERTY; REACTION WITH NUCLEOPHILES; CYTOTOXICITY;

D O I：

10.1016/S0040-4039(00)76798-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the title compounds was achieved by employing condensation of the 2-methoxy-1-pyrroline with ethyl nitroacetate and construction of 1-azabicyclo[3.1.0]hexane systems from 5-mesyloxymethylpyrrolidines as key steps. Some of these congeners which carry a C-6-C-11 unit involving the naphthalene part, were found to exhibit prominent cytotoxicity and effectively alkylate nucleophiles at both the aziridine and epoxide moieties.

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页码：2207 / 2210

页数：4

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