EXPERIMENTAL IMMUNITY AGAINST TRYPANOSOMIASIS IN RABBITS

被引：6

作者：

POWELL, C ^{[1
]}

机构：

[1] INT CTR INSECT PHYSIOL & ECOL,NAIROBI,KENYA

来源：

VACCINE | 1993年 / 11卷 / 03期

关键词：

TRYPANOSOMIASIS; EXPERIMENTAL IMMUNITY; HETEROLOGOUS STRAIN; HOMOLOGOUS STRAIN;

D O I：

10.1016/0264-410X(93)90191-Y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rabbits were immunized with specially prepared subcellular fractions of a cloned Trypanosoma brucei brucei stock 427. One fraction was found to be highly immunoprophylactic in rabbits exposed to the vector fly genus Glossina m. morsitans (tsetse flies) infected with EATRO Trypanosoma brucei brucei 1969. The most immunoprotective fraction IPF(A) from T. b. brucei 427 gave 75% protection to animals challenged by EATRO T. b. brucei 1969. IPF(A) also showed the highest IgG antibody titre against the heterologous and homologous strains. In in vitro studies, the sera from these immunized rabbits killed different strains of parasites, T. b. brucei strains 1969 and 999 which were grown in continuous culture of salivary gland cells from G. m. morsitans.

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页码：307 / 310

页数：4

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