ISOLATION OF ANTIRHINOVIRAL SESQUITERPENES FROM GINGER (ZINGIBER-OFFICINALE)

被引：80

作者：

DENYER, CV ^{[1
]}

JACKSON, P ^{[1
]}

LOAKES, DM ^{[1
]}

ELLIS, MR ^{[1
]}

YOUNG, DAB ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT MOLEC SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 05期

关键词：

D O I：

10.1021/np50107a017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dried rhizomes of Indonesian ginger, Zingiber officinale, were investigated for antirhinoviral activity in the plaque reduction rest. Fractionation by solvent extraction, solvent partition, and repeated chromatography guided by bioassay, allowed the isolation of several sesquiterpenes with antirhinoviral activity. The most active of these was beta-sesquiphellandrene [2] with an IC50 of 0.44 mu M vs. rhinovirus IB in vitro.

引用

页码：658 / 662

页数：5

共 21 条

[1] 4',6-DICHLOROFLAVAN (BW683C), A NEW ANTI-RHINOVIRUS COMPOUND [J].

BAUER, DJ ;

SELWAY, JWT ;

BATCHELOR, JF ;

TISDALE, M ;

CALDWELL, IC ;

YOUNG, DAB .

NATURE, 1981, 292 (5821) :369-370

[2] A NOVEL METHOD FOR DETECTING THE ANTIVIRAL ACTIVITY OF FLAVANS IN THEIR VAPOR-PHASE [J].

BAUER, DJ ;

SELWAY, JWT .

ANTIVIRAL RESEARCH, 1983, 3 (04) :235-239

[3]

CONNELL D. W., 1970, Flavour Industry, V1, P677

[4]

CONNELL DW, 1966, AUST J CHEM, V19, P283

[5] STUDIES IN SESQUITERPENES .37. SESQUITERPENOIDS FROM ESSENTIAL OIL OF ZINGIBER ZERUMBET SMITH [J].

DAMODARAN, NP ;

DEV, S .

TETRAHEDRON, 1968, 24 (11) :4113-+

[6] SYNTHESES AND ABSOLUTE-CONFIGURATION OF (E)-ALPHA-BISABOLENES AND (Z)-ALPHA-BISABOLENES [J].

DELAY, F ;

OHLOFF, G .

HELVETICA CHIMICA ACTA, 1979, 62 (02) :369-377

[7] ENHANCEMENT OF RHINOVIRUS PLAQUE FORMATION IN HUMAN HETEROPLOID CELL CULTURES BY MAGNESIUM AND CALCIUM [J].

FIALA, M ;

KENNY, GE .

JOURNAL OF BACTERIOLOGY, 1966, 92 (06) :1710-&

[8] EFFICIENT SYNTHESES OF BETA-SESQUIPHELLANDRENE AND ZINGIBERENOL EMPLOYING A TANDEM ARYLATION-MULTISTEP REDUCTION-HYDROLYSIS SEQUENCE [J].

FLISAK, JR ;

HALL, SS .

SYNTHETIC COMMUNICATIONS, 1986, 16 (10) :1217-1228

[9]

GOVINDARAJAN VS, 1982, CRC CR REV FOOD SCI, V17, P189

[10] CHROMATOGRAPHY OF ORGANIC COMPOUNDS .1. THIN-LAYER CHROMATOGRAPHY OF OLEFINS [J].

GUPTA, AS ;

DEV, S .

JOURNAL OF CHROMATOGRAPHY, 1963, 12 (02) :189-&

← 1 2 3 →