CELL RECEPTOR-INDEPENDENT INFECTION BY A NEUROTROPIC MURINE CORONAVIRUS

被引：68
作者：
GALLAGHER, TM
BUCHMEIER, MJ
PERLMAN, S
机构：
[1] UNIV IOWA, DEPT PEDIAT, IOWA CITY, IA 52242 USA
[2] UNIV IOWA, DEPT MICROBIOL, IOWA CITY, IA 52242 USA
[3] Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, DIV VIROL, LA JOLLA, CA 92037 USA
来源：
VIROLOGY | 1992年 / 191卷 / 01期
关键词：
D O I：
10.1016/0042-6822(92)90223-C
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts. © 1992.
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收藏
页码：517 / 522
页数：6
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