PROTECTIVE EFFECTS OF A LIVE ATTENUATED SIV VACCINE WITH A DELETION IN THE NEF GENE

被引：951

作者：

DANIEL, MD ^{[1
]}

KIRCHHOFF, F ^{[1
]}

CZAJAK, SC ^{[1
]}

SEHGAL, PK ^{[1
]}

DESROSIERS, RC ^{[1
]}

机构：

[1] HARVARD UNIV,NEW ENGLAND REG PRIMATE RES CTR,SCH MED,1 PINE HILL DR,BOX 9102,SOUTHBOROUGH,MA 01772

来源：

SCIENCE | 1992年 / 258卷 / 5090期

关键词：

D O I：

10.1126/science.1470917

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the persistent, unrelenting nature of HIV and SIV infection once infection is initiated. SIV with a constructed deletion in the auxiliary gene nef replicates poorly in rhesus monkeys and appears to be nonpathogenic in this normally susceptible host. Rhesus monkeys vaccinated with live SIV deleted in nef were completely protected against challenge by intravenous inoculation of live, pathogenic SIV. Deletion of nef or of multiple genetic elements from HIV may provide the means for creating a safe, effective, live attenuated vaccine to protect against acquired immunodeficiency syndrome (AIDS).

引用

页码：1938 / 1941

页数：4

共 26 条

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