ARYLOXY ACETIC-ACID DIURETICS WITH URICOSURIC ACTIVITY .1. POLYCYCLIC ARYLOXY ACETIC-ACIDS

被引：0
|
作者：
KITAGAWA, M
MIMURA, T
TANAKA, M
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 09期
关键词：
ARYLOXY ACETIC ACID; 2,3-DIHYDRO-1-OXO-1H-ISOINDOLE; 3,4-DIHYDRO-4-OXO-3H-QUINAZOLINE; 4-OXO-4H-1-BENZOPYRAN; XANTHONE; BENZO[B]FURAN; INDENE; ((5-CHLORO-4-OXO-3-PHENYL-4H-1-BENZOPYRAN-7-YL)OXY)ACETIC ACID; DIURETIC; URICOSURIC; ANTIHYPERTENSIVE ACTIVITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In order to obtain lead compounds for uricosuric diuretics, various polycyclic aryloxy acetic acids [isoindole derivative (7), quinazoline derivative (15), benzopyran derivative (20), xanthone derivative (24), benzofuran derivative (30) and indene derivative (36)] were prepared. These compounds were evaluated for diuretic activity in rats, uricosuric activity in rats and antihypertensive activity in 11-deoxycorticosterone acetate (DOCA)/salt hypertensive rats. Among the compounds, 20 showed potent diuretic, uricosuric and moderate antihypertensive activities. Therefore, we selected 20 as a lead compound for development of new uricosuric diuretics.
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页码：2400 / 2407
页数：8
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