EFFECTS OF EXERCISE ON PLASMA-LIPOPROTEIN LEVELS AND ENDOTHELIUM-DEPENDENT VASODILATATION IN YOUNG AND OLD RATS

被引:17
作者
HASHIMOTO, M
机构
[1] Department of Physiology, Shimane Medical University, Izumo, Shimane
来源
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY | 1990年 / 61卷 / 5-6期
关键词
EXERCISE; LOW AND HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ENDOTHELIUM-DEPENDENT RELAXATION; RAT AORTA; AGING;
D O I
10.1007/BF00236065
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Effects of treadmill exercise (1 h.day-1 for 12 weeks) on the mechanical properties of isolated aortae and plasma concentrations of low and high density lipoprotein cholesterols ([LDL-C]pl and [HDL-C]pl, respectively) were investigated in young (16 weeks) and old (98 weeks) rats. With aging, [LDL-C]pl increased and acetylcholine (ACh) elicited greater endothelium-dependent relaxations of the aorta in old rats than in young rats. Also, in all groups of rats tested (young, old, exercised and nonexercised), the increase in the ]LDL-C[pl correlated with an increase in the sensitivity of relaxation of the aorta to ACh. On the other hand, a greater [HDL-C]pl was associated with a smaller relaxation response to ACh in young rats only when exercised and nonexercised groups were combined. The increase in [HDL-C]pl with aging, however, did not correlate with the extent of ACh-induced relaxation. Exercise in old rats reduced [LDL-C]pl and the extent of ACh-induced relaxation of the aorta. Therefore, [LDL-C]pl appeared to be closely related to the extent of endothelium-dependent relaxation in response to ACh in the aorta. The [LDL-C]pl also correlated with the gain in mass of the rat. Exercise in old rats reduced the body mass and was accompanied by a decrease in [LDL-C]pl.
引用
收藏
页码:440 / 445
页数:6
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