LIQUID-CHROMATOGRAPHIC EVALUATION OF A NEW CHIRAL DERIVATIZING REAGENT FOR ENANTIOMERIC RESOLUTION OF AMINE AND ALCOHOL DRUGS

被引：5
作者：
ZHOU, Y
SUN, ZP
LIN, DK
机构：
[1] National Institute for the Control of Pharmaceutical and Biological Products, People’s Republic of China, Beijing
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 05期
关键词：
D O I：
10.1080/01483919008049219
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new chiral resolving reagent N-(p-toluenesulfo-nyl)prolyl isocyanate(TSPI) was prepared with a very practical method and evaluated for liquid chromatographic resolution of amine and alcohol enantiomers via diastereomerie derivatization. This procedure is rapid and convenient, with good separation, few byproducts. Expected structures of the derivatives were confirmed by mass spectra. Ordinary normal phase and the mobile phase of petroleum ether were used. © 1990, Taylor & Francis Group, LLC. All rights reserved.
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页码：875 / 885
页数：11
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