BIOSYNTHESIS OF AFLATOXIN-B1 - CONVERSION OF VERSICOLORIN-A TO AFLATOXIN-B1 BY ASPERGILLUS-PARASITICUS

被引：71

作者：

LEE, LS ^{[1
]}

BENNETT, JW ^{[1
]}

CUCULLU, AF ^{[1
]}

ORY, RL ^{[1
]}

机构：

[1] USDA, ARS, SO REG RES CTR, SO REG, NEW ORLEANS, LA 70179 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1976年 / 24卷 / 06期

关键词：

D O I：

10.1021/jf60208a017

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Forty-six percent of added [14C]versicolorin A was efficiently converted to aflatoxin B1 by a resting cell culture of wild-type A. parasiticus. The labeled pigment was isolated from [1-14C]acetate enriched cultures of a mutant of A. parasiticus that elaborates several versicolorin pigments, but no aflatoxins. The high level of incorporation into aflatoxin B1 and the relative specific activity of 0.475 of aflatoxin B1 isolated from the culture of A. parasiticus enriched with [14C]versicolorin A indicate that this C-18 polyketide-derived hydroxyanthraquinone is a precursor to aflatoxin B1.

引用

页码：1167 / 1170

页数：4

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