p53 isoforms change p53 paradigm

被引：14

作者：

Bourdon, J. C. ^{[1
]}

机构：

[1] Univ Dundee, Coll Med, Div Canc Res, Dundee Canc Ctr, Dundee, Scotland

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2014年 / 1卷 / 04期

关键词：

cancer; cdc2-like-kinase; clk; p63; p73; splicing; SRSF1;

D O I：

10.4161/23723548.2014.969136

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.

引用

页数：2

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