REGULATORY SQUELCHING

被引：67

作者：

CAHILL, MA ^{[1
]}

ERNST, WH ^{[1
]}

JANKNECHT, R ^{[1
]}

NORDHEIM, A ^{[1
]}

机构：

[1] HANNOVER MED SCH,INST MOLEK BIOL,D-30623 HANNOVER,GERMANY

来源：

FEBS LETTERS | 1994年 / 344卷 / 2-3期

关键词：

TRANSCRIPTION REGULATION; TRANSCRIPTION FACTOR;

D O I：

10.1016/0014-5793(94)00320-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be more important than hitherto appreciated.

引用

页码：105 / 108

页数：4

共 45 条

[1] THE ROLE OF JUN, FOS AND THE AP-1 COMPLEX IN CELL-PROLIFERATION AND TRANSFORMATION [J].

ANGEL, P ;

KARIN, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :129-157

[2]

BENGAL E, 1992, CELL, V68, P597

[3] HOX GENE ACTIVATION BY RETINOIC ACID [J].

BONCINELLI, E ;

SIMEONE, A ;

ACAMPORA, D ;

MAVILIO, F .

TRENDS IN GENETICS, 1991, 7 (10) :329-334

[4] THE ONCOPROTEIN BCL-3 DIRECTLY TRANSACTIVATES THROUGH KAPPA-B MOTIFS VIA ASSOCIATION WITH DNA-BINDING P50B HOMODIMERS [J].

BOURS, V ;

FRANZOSO, G ;

AZARENKO, V ;

PARK, S ;

KANNO, T ;

BROWN, K ;

SIEBENLIST, U .

CELL, 1993, 72 (05) :729-739

[5] DISTINCT TFIID COMPLEXES MEDIATE THE EFFECT OF DIFFERENT TRANSCRIPTIONAL ACTIVATORS [J].

BROU, C ;

CHAUDHARY, S ;

DAVIDSON, I ;

LUTZ, Y ;

WU, J ;

EGLY, JM ;

TORA, L ;

CHAMBON, P .

EMBO JOURNAL, 1993, 12 (02) :489-499

[6]

CROSTON GE, 1992, GENE DEV, V6, P2279

[7] UNREGULATED EXPRESSION OF C-JUN OR C-FOS PROTEINS BUT NOT JUN-D INHIBITS ESTROGEN-RECEPTOR ACTIVITY IN HUMAN BREAST-CANCER DERIVED CELLS [J].

DOUCAS, V ;

SPYROU, G ;

YANIV, M .

EMBO JOURNAL, 1991, 10 (08) :2237-2245

[8] CARBOXY-TERMINAL ELEMENTS OF C-MYB NEGATIVELY REGULATE TRANSCRIPTIONAL ACTIVATION IN CIS AND IN TRANS [J].

DUBENDORFF, JW ;

WHITTAKER, LJ ;

ELTMAN, JT ;

LIPSICK, JS .

GENES & DEVELOPMENT, 1992, 6 (12B) :2524-2535

[9] ISOLATION OF COACTIVATORS ASSOCIATED WITH THE TATA-BINDING PROTEIN THAT MEDIATE TRANSCRIPTIONAL ACTIVATION [J].

DYNLACHT, BD ;

HOEY, T ;

TJIAN, R .

CELL, 1991, 66 (03) :563-576

[10]

ERNST WH, 1994, UNPB

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