MORPHINE SUPPRESSES THE OVARIAN-STEROID HORMONE-DEPENDENT LORDOSIS RESPONSE OF FEMALE GUINEA-PIGS - REVERSAL BY NALOXONE BUT NOT CLONIDINE

The opiate agonist morphine caused a dose- and time-dependent suppression of lordosis responding in ovariectomized guinea pigs treated with estradiol-17β and progesterone. The suppression of lordosis by morphine appears to be mediated by opiate receptors since the opiate antagonist naloxone blocked its effects both in terms of the percentage of animals showing lordosis and the duration of individual responses. Naloxone, when given alone, did not affect lordosis responding in estradiol-17β + progesterone-primed animals and did not induce lordosis in animals primed with estradiol-17β alone. Thus, endogenous opioids might not tonically inhibit lordosis under the physiological conditions examined. The α-noradrenergic agonist clonidine did not reverse the effects of morphine on lordosis. Thus, the inhibitory effects of morphine on this behavior might be independent of its presynaptic effects on norepinephrine release in brain. © 1991.