CLONING, SEQUENCING AND ANALYSIS OF THE STRUCTURAL GENE AND REGULATORY REGION OF THE PSEUDOMONAS-AERUGINOSA CHROMOSOMAL AMPC BETA-LACTAMASE

被引：108

作者：

LODGE, JM ^{[1
]}

MINCHIN, SD ^{[1
]}

PIDDOCK, LJV ^{[1
]}

BUSBY, SJW ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT MED MICROBIOL,ANTIMICROBIAL AGENTS RES GRP,BIRMINGHAM B5 2TJ,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1990年 / 272卷 / 03期

关键词：

D O I：

10.1042/bj2720627

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chromosomal gene from Pseudomonas aeruginosa encoding beta-lactamase has been cloned, and the sequence determined and compared with corresponding sequences of beta-lactamases from members of the enterobacteriaceae. Upstream of the beta-lactamase gene is an open reading frame which we postulate encodes a regulatory protein, AmpR. We identified a helix-turn-helix region in AmpR and a putative AmpR-binding site.

引用

页码：627 / 631

页数：5

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