Hepatoprotective Activity of Methanol Extract of Melastoma malabathricum Leaf in Rats

被引：10

作者：

Kamisan, Farah Hidayah ^{[1
]}

Yahya, Farhana ^{[1
]}

Ismail, Noor Aisyah ^{[1
]}

Din, Syafawati Shamsahal ^{[1
]}

Mamat, Siti Syariah ^{[1
]}

Zabidi, Zalina ^{[1
]}

Zainulddin, Wan Noraziemah Wan ^{[1
]}

Mohtarrudin, Norhafizah ^{[2
]}

Husain, Hadijah ^{[3
]}

Ahmad, Zuraini ^{[1
]}

Zakaria, Zainul Amiruddin ^{[1
,4
]}

机构：

[1] Univ Putra Malaysia, Dept Biomed Sci, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Pathol, Serdang, Selangor, Malaysia

[3] Malaysian Agr Res Inst MARDI, Biotechnol Res Ctr, Ctr Food Technol Res, Kuala Lumpur, Malaysia

[4] Univ Teknol MARA, Fac Pharm, Pharmacogen Ctr PROMISE, Serdang, Selangor, Malaysia

来源：

JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES | 2013年 / 6卷 / 01期

关键词：

hepatoprotective activity; in vivo; leaves; Melastoma malabathricum; Melastomaceae; methanol extract;

D O I：

10.1016/j.jams.2012.08.002

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastomamalabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n = 6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (positive control), or MEMM (50, 250, or 500 mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p < 0.05) hepatoprotective activity against both inducers, as indicated by an improvement in the liver function test. These observations were supported by the histologic findings. In conclusion, M. malabathricum leaves possessed hepatoprotective activity, which could be linked to their phytochemical constituents and antioxidant activity; this therefore requires further in-depth studies.

引用

页码：52 / 55

页数：4

共 16 条

[1] Arhoghro E, 2009, EUR J SCI RES, V26, P122
[2] Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract:: Part II
Chattopadhyay, RR
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2003, 89 (2-3) : 217 - 219
[3] Dash DK, 2007, TROP J PHARM RES, V6, P755
[4] Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue
Dursun, Hakan
Bilici, Mehmet
Albayrak, Fatih
Ozturk, Cengiz
Saglam, Mustafa B.
Alp, Hamit H.
Suleyman, Halis
[J]. BMC GASTROENTEROLOGY, 2009, 9
[5] El-Sawi S. A., 2010, Australian Journal of Basic and Applied Sciences, V4, P1326
[6] Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay
Guo, CJ
Yang, JJ
Wei, JY
Li, YF
Xu, J
Jiang, YG
[J]. NUTRITION RESEARCH, 2003, 23 (12) : 1719 - 1726
[7] Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review
Joffry, S. Mohd.
Yob, N. J.
Rofiee, M. S.
Affandi, M. M. R. Meor Mohd.
Suhaili, Z.
Othman, F.
Akim, A. Md.
Desa, M. N. M.
Zakaria, Z. A.
[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 2012
[8] Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis)
Le Tran, Q
Adnyana, IK
Tezuka, Y
Harimaya, Y
Salki, L
Kurashige, Y
Tran, QK
Kadota, S
[J]. PLANTA MEDICA, 2002, 68 (05) : 402 - 406
[9] Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus
Mohamed, Elsnoussi Ali Hussin
Lim, Chung Pin
Ebrika, Omar Saad
Asmawi, Mohd Zaini
Sadikun, Amirin
Yam, Mun Fei
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2011, 133 (02) : 358 - 363
[10] In vivo hepatoprotective effects of Rhoicissus tridentata subsp cuneifolia, a traditional Zulu medicinal plant, against CCl4-induced acute liver injury in rats
Opoku, A. R.
Ndlovu, I. M.
Terblanche, S. E.
Hutchings, A. H.
[J]. SOUTH AFRICAN JOURNAL OF BOTANY, 2007, 73 (03) : 372 - 377

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