EFFECTS OF THE MAJOR METABOLITE OF PHENCYCLIDINE, THE TRANS ISOMER OF 4-PHENYL-4-(1-PIPERIDINYL)CYCLOHEXANOL, ON [H-3] N-(1-[2-THIENYL]CYCLOHEXYL)-3,4-PIPERIDINE ([H-3]TCP) BINDING AND [H-3] DOPAMINE UPTAKE IN THE RAT-BRAIN

被引：2
|
作者：
BABA, A
YAMAMOTO, T
YAMAMOTO, H
SUZUKI, T
MOROJI, T
机构：
[1] TOKYO INST PSYCHIAT,DEPT PSYCHOPHARMACOL,SETAGAYA KU,TOKYO 156,JAPAN
[2] UNIV TSUKUBA HOSP,PSYCHIAT SERV,TSUKUBA,IBARAKI,JAPAN
[3] YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,MOLEC RECOGNIT LAB,YOKOHAMA,KANAGAWA,JAPAN
[4] UNIV TSUKUBA,INST CLIN MED,DEPT PSYCHIAT,TSUKUBA,IBARAKI,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 182卷 / 01期
关键词：
PHENCYCLIDINE; TRANS ISOMER OF 4-PHENYL-4-(1-PIPERIDINYL)CYCLOHEXANOL; H-3] TCP BINDING; H-3] DA UPTAKE; RAT BRAIN;
D O I：
10.1016/0304-3940(94)90221-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The major metabolite of phencyclidine (PCP), the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol [(trans)4-PPC], inhibited [H-3]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine ([H-3]TCP) binding to well-washed rat cortical membranes with much less activity than PCP itself. In contrast, it inhibited [H-3]dopamine ([H-3]DA) uptake in rat striatal synaptosomes to a similar extent as PCP. Considering our previous observations that intraperitoneally administered (trans)-4-PPC elicits dose-related increases in locomotor activity and rearing in mice, (trans)4-PPC as well as PCP may be involved in psychotomimetic effects of PCP due to its inhibitory effect on DA uptake.
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页码：119 / 121
页数：3
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