EFFECTS OF C-TERMINAL PARATHYROID HORMONE-RELATED PEPTIDE ON OSTEOBLASTS

被引：0
|
作者：
SEITZ, PK
ZHANG, RW
SIMMONS, DJ
COOPER, CW
机构：
[1] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL & TOXICOL,GALVESTON,TX 77555
[2] UNIV TEXAS,MED BRANCH,DEPT SURG,GALVESTON,TX 77555
来源：
MINERAL AND ELECTROLYTE METABOLISM | 1995年 / 21卷 / 1-3期
关键词：
CAMP; OSTEOBLAST; PARATHYROID HORMONE-RELATED PEPTIDE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A C-terminal analog of parathyroid hormone-related peptide (PTHrP), PTHrP(107-139), was found to stimulate cAMP production in three osteoblast cell preparations. The effect was studied most extensively in ROS 17/2.8 cells. The effect was dose-related and comparable in magnitude to that produced by PTHrP(1-34), but potency was lower. The functional significance of the cAMP effect is unknown, but preliminary findings indicated that PTHrP(107-139) also inhibited osteopontin mRNA levels in ROS 17/2.8 cells treated with peptide for 48 h. The results suggest that the carboxy-terminal region of PTHrP may play a role in bone metabolism by influencing osteoblast activity.
引用
收藏
页码：180 / 183
页数：4
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