THE GP-PROTEIN OF MARBURG VIRUS CONTAINS THE REGION SIMILAR TO THE IMMUNOSUPPRESSIVE DOMAIN OF ONCOGENIC RETROVIRUS P15E PROTEINS

被引：33

作者：

BUKREYEV, AA

VOLCHKOV, VE

BLINOV, VM

NETESOV, SV

机构：

[1] NPO 'VECTOR', Institute of Molecular Biology, 633159 Koltsovo, Novosibirsk Region

来源：

FEBS LETTERS | 1993年 / 323卷 / 1-2期

关键词：

MARBURG VIRUS; FILOVIRIDAE; CDNA; ENVELOPE PROTEIN; IMMUNOSUPPRESSIVE DOMAIN;

D O I：

10.1016/0014-5793(93)81476-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNA was synthesized and cloned on the template of the genomic RNA of Marburg virus (strain Popp). Recombinant plasmids with specific cDNA inserts were selected and sequenced. The length of the open reading frame encoding the GP-protein is 681 amino acids. GP-protein is proposed to be an integral membrane protein. Computer-assisted comparison of the deduced amino acid sequence with those of different viruses revealed significant homology with the GP-protein of Ebola virus and with the 'immunosuppressive domain' of the P15E envelope proteins of some oncogenic retroviruses.

引用

页码：183 / 187

页数：5

共 25 条

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