CHOLESTEROL-METABOLISM - ITS REGULATION AT THE HEPATIC AND INTESTINAL LEVEL

被引：3

作者：

MOLINA, MT

VAZQUEZ, CM

GUTIERREZ, VR

机构：

[1] Facultad de Farmacia, Universidad de Sevilla

[2] Instituto de la Grasa y sus Derivados, Avda. Padre García Tejero, 4, Sevilla

来源：

GRASAS Y ACEITES | 1991年 / 42卷 / 04期

关键词：

CHOLESTEROL (METABOLISM); ENZYMATIC ACTIVITY; INFORMATION (PAPER); LIPID COMPOSITION; MEMBRANE;

D O I：

10.3989/gya.1991.v42.i4.1237

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Although all the cells in the body are able to form cholesterol, most part of this synthesis, leading to which is called endogenous cholesterol, occurs in the liver. Hepatocytes can also obtain cholesterol from the plasma lipoproteins. At the same time, cholesterol is either secreted from the liver in new plasma lipoproteins or transformed in bile acids. The extrahepatic cholesterol is mainly produced in the intestinal mucosa. In the site, it takes place the absorption of cholesterol from the diet (exogenous cholesterol), along with the biosynthesis of new cholesterol and the esterification of the molecule to be stored in the cell or secreted as plasma lipoproteins. At the cellular level, the importance of cholesterol comes from the fact that many of the membranous structures of all cells are partially composed of these substance. In this article some of these aspects of the cholesterol metabolism are reviewed. We also describe the influence of lipid composition of microsomal membranes on the activity of cholesterol metabolism regulating enzymes.

引用

页码：298 / 308

页数：11

共 62 条

[1]

Brown M.S., Goldstein M., General scheme for regulation of cholesterol metabolism in mammalian cells, Disturbances in Lipid and Lipoproteins Metabolism, pp. 173-180, (1978)

[2]

Gill J.R., Control mechanism in sterol uptake and biosynthesis, Sterols and Bile Acids, (1985)

[3]

Kenelly P.J., Rodwell J.W., Regulation of 3-hydroxy-3-methylglutaryl coenzime A reductase by reversible phosphorilation-dephosphorilation, J. Lipid Res., 26, pp. 903-914, (1985)

[4]

Shapiro D.J., Rodwell V.W., Regulation of 3-hydroxy-3-methylglutaryl coenzime A reductase and cholesterol synthesis, J. Biol. Chem., 246, pp. 3210-3216, (1971)

[5]

Ramirez H., Alejandre M.J., Segovia J.L., Garcia-Peregrin E., Development of the diurnal, rythm of chick 3-hydroxy-3-methylglutaryl-coa-reductase, Lipids, 17, pp. 434-436, (1982)

[6]

Mitropoulos K.A., Balasubramanian S., Venkatesan S., Reeves B.E.A., On the mechanisms for the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase, of cholesterol 7α-hydroxylase and of acyl-coenzyme A: Cholesterol acyltransferase by free cholesteror, Biochim. Biophys. Acta, 530, pp. 99-110, (1978)

[7]

Ramirez H., Alejandre M.J., Segovia J.L., Garcia-Peregrin E., Different thermal behavior of neonatal hepatic and cerebral 3-hydroxy-3-methylglutaryl-coa-reductase, Lipids, 16, pp. 552-554, (1978)

[8]

Sabine J.R., James M.J., The intracellular mechanism responsible for dietary back control of cholesterol synthesis, Life Sci., 18, pp. 1185-1192, (1978)

[9]

Rodwell V.M., McNamara D.J., Shapiro D.J., Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzime A reductase, Adv. Enzymoi, 38, pp. 373-412, (1973)

[10]

Brown M.S., Goldstein J.L., Dietschy J.M., Active and inactive forms of 3-hidroxy-3-methylglutryl coenzime A reductase in the liver of the rat. Comparision with rate of cholesterol synthesis in different physiological states, J. Biol. Chem., 254, 12, pp. 5144-5149, (1979)

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