T-CELL AND BASOPHIL ACTIVATION THROUGH THE CYTOPLASMIC TAIL OF T-CELL-RECEPTOR ZETA-FAMILY PROTEINS

被引:296
作者
LETOURNEUR, F
KLAUSNER, RD
机构
关键词
D O I
10.1073/pnas.88.20.8905
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The zeta-chain of the T-cell antigen receptor is the prototype of a family of proteins that exist as disulfide-linked dimers and are subunits of the T-cell antigen receptor and both IgE and IgG binding Fc receptors. Two related genes encode the zeta and gamma-proteins. In this study we examine the ability of chimeric proteins consisting of the extracellular domain of the alpha-chain of the interleukin 2 receptor (Tac) and the cytoplasmic domain of either zeta or gamma to activate cells when expressed in either T cells or rat basophilic leukemia cells. The zeta and gamma-chimera were effective at eliciting interleukin 2 production in T cells and serotonin release in rat basophilic leukemia cells when externally cross-linked. Cytoplasmic-tail deletion mutants of zeta and gamma were constructed and used to verify the specificity of cell activation by these chimeric proteins. Signaling potencies of complementary mutants having the zeta-tail truncated in position 108 or deleted from positions 66 through 114 suggested the presence of several functional domains in zeta.
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页码:8905 / 8909
页数:5
相关论文
共 46 条
[1]   CD3-NEGATIVE NATURAL-KILLER CELLS EXPRESS ZETA-TCR AS PART OF A NOVEL MOLECULAR-COMPLEX [J].
ANDERSON, P ;
CALIGIURI, M ;
RITZ, J ;
SCHLOSSMAN, SF .
NATURE, 1989, 341 (6238) :159-162
[2]   FC-GAMMA RECEPTOR TYPE-III (CD16) IS INCLUDED IN THE ZETA-NK RECEPTOR COMPLEX EXPRESSED BY HUMAN NATURAL-KILLER-CELLS [J].
ANDERSON, P ;
CALIGIURI, M ;
OBRIEN, C ;
MANLEY, T ;
RITZ, J ;
SCHLOSSMAN, SF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) :2274-2278
[3]   CELL-GROWTH CYCLE BLOCK OF T-CELL HYBRIDOMAS UPON ACTIVATION WITH ANTIGEN [J].
ASHWELL, JD ;
CUNNINGHAM, RE ;
NOGUCHI, PD ;
HERNANDEZ, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (01) :173-194
[4]  
BANIYASH M, 1988, J BIOL CHEM, V263, P18225
[5]   SELECTIVE DEGRADATION OF T-CELL ANTIGEN RECEPTOR CHAINS RETAINED IN A PRE-GOLGI COMPARTMENT [J].
CHEN, C ;
BONIFACINO, JS ;
YUAN, LC ;
KLAUSNER, RD .
JOURNAL OF CELL BIOLOGY, 1988, 107 (06) :2149-2161
[6]   THE T-CELL RECEPTOR/CD3 COMPLEX - A DYNAMIC PROTEIN ENSEMBLE [J].
CLEVERS, H ;
ALARCON, B ;
WILEMAN, T ;
TERHORST, C .
ANNUAL REVIEW OF IMMUNOLOGY, 1988, 6 :629-662
[7]   STRUCTURE OF THE T-CELL ANTIGEN RECEPTOR (TCR) - 2 CD3-EPSILON SUBUNITS IN A FUNCTIONAL TCR/CD3 COMPLEX [J].
DELAHERA, A ;
MULLER, U ;
OLSSON, C ;
ISAAZ, S ;
TUNNACLIFFE, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01) :7-17
[8]  
EISEMAN E, 1990, CANCER CELL-MON REV, V2, P303
[9]   STRUCTURAL MUTATIONS OF THE T-CELL RECEPTOR ZETA-CHAIN AND ITS ROLE IN T-CELL ACTIVATION [J].
FRANK, SJ ;
NIKLINSKA, BB ;
ORLOFF, DG ;
MERCEP, M ;
ASHWELL, JD ;
KLAUSNER, RD .
SCIENCE, 1990, 249 (4965) :174-177
[10]   T-CELL-ACTIVATING PROPERTIES OF AN ANTI-THY-1 MONOCLONAL-ANTIBODY - POSSIBLE ANALOGY TO OKT3/LEU-4 [J].
GUNTER, KC ;
MALEK, TR ;
SHEVACH, EM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 159 (03) :716-730