NONUNIFORM SIZE DISTRIBUTION OF NASCENT GLOBIN PEPTIDES, EVIDENCE FOR PAUSE LOCALIZATION SITES, AND A COTRANSLATIONAL PROTEIN-FOLDING MODEL

被引：40

作者：

KRASHENINNIKOV, IA ^{[1
]}

KOMAR, AA ^{[1
]}

ADZHUBEI, IA ^{[1
]}

机构：

[1] MV LOMONOSOV STATE UNIV,FAC BIOL,DEPT MOLEC BIOL,MOSCOW 119899,USSR

来源：

JOURNAL OF PROTEIN CHEMISTRY | 1991年 / 10卷 / 05期

关键词：

NONRANDOM CODON UTILIZATION; NONUNIFORM TRANSLATION; NASCENT PEPTIDES; 3-DIMENSIONAL PROTEIN STRUCTURE; COTRANSLATIONAL FOLDING;

D O I：

10.1007/BF01025472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Examination of nascent globin peptides accumulating in vitro during globin synthesis in rabbit reticulocyte lysates was carried out. A view was supported that nonrandom distribution of codons with different usage frequencies in mRNA may determine the messenger's translation kinetics. Regions of reduced translation of alpha- and beta-globin polypeptide chains were localized, and the cotranslational protein-folding model suggested previously was substantiated. An active conjunction of synthesis and folding of proteins was proposed as one of the main destinations of a translation nonuniformity.

引用

页码：445 / 453

页数：9

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