Emerging role of cell polarity proteins in breast cancer progression and metastasis

被引：39

作者：

Chatterjee, Sudipa June ^{[1
]}

McCaffrey, Luke ^{[1
]}

机构：

[1] McGill Univ, Dept Oncol, Rosalind & Morris Goodman Canc Ctr, 1160 Pine Ave West, Montreal H3A 1A3, PQ, Canada

来源：

BREAST CANCER-TARGETS AND THERAPY | 2014年 / 6卷

基金：

加拿大健康研究院;

关键词：

apical; basal; oncogene; tumor suppressor; proliferation; apoptosis;

D O I：

10.2147/BCTT.S43764

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is a heterogeneous group of diseases that frequently exhibits loss of growth control, and disrupted tissue organization and differentiation. Several recent studies indicate that apical-basal polarity provides a tumor-suppressive function, and that disrupting polarity proteins affects many stages of breast cancer progression from initiation through metastasis. In this review we highlight some of the recent advances in our understanding of the molecular mechanisms by which loss of apical-basal polarity deregulatesapoptosis, proliferation, and promotes invasion and metastasis in breast cancer.

引用

收藏

页码：15 / 27

页数：13

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