T-LYMPHOCYTES BEARING THE GAMMA-DELTA T-CELL RECEPTOR IN CUTANEOUS LESIONS OF LANGERHANS CELL HISTIOCYTOSIS

被引：6
作者：
ALAIBAC, M
CHU, AC
机构：
[1] Unit of Dermatology, Royal Postgraduate Medical School, Hammersmith Hospital, London
来源：
MEDICAL AND PEDIATRIC ONCOLOGY | 1993年 / 21卷 / 05期
关键词：
LANGERHANS CELL HISTIOCYTOSIS (LCH); GAMMA-DELTA T-CELLS; T-CELL RECEPTOR (TCR);
D O I：
10.1002/mpo.2950210507
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to investigate the regional importance of gammadelta T cells in cutaneous lesions of Langerhans' cell histiocytosis. Six cases of Langerhans' cell histiocytosis were investigated by immunohistochemical techniques (alkaline phosphatase-antialkaline phosphatase complex and indirect immunoperoxidase). Increase of gammadelta T cells was observed in 3 cases of Langerhans' cell histiocytosis. In these cases up to 30% of CD3+ cells stained with an anti-TCR gammadelta monoclonal antibodies and in two of them gammadelta T cells showed a marked epidermotropism. In the specimens of the remaining three cases gammadelta T cells were found in an overall percentage of 5% of CD3+ cells, but in two cases a significant increase of epidermal gammadelta T cells was observed. The finding of numerous gammadelta T cells in Langerhans' cell histiocytosis is provocative and supports the suggestion of a functional relationship between gammadelta T cells and LCH cells.
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收藏
页码：347 / 349
页数：3
相关论文
共 22 条
[1]   IMMUNOCHEMICAL PROOF THAT A NOVEL REARRANGING GENE ENCODES THE T-CELL RECEPTOR-DELTA SUBUNIT [J].
BAND, H ;
HOCHSTENBACH, F ;
MCLEAN, J ;
HATA, S ;
KRANGEL, MS ;
BRENNER, MB .
SCIENCE, 1987, 238 (4827) :682-684
[2]  
BERTI E, 1988, LANGERHANS CELLS, P467
[3]  
BORN W, 1990, IMMUNOL TODAY, V11, P40
[4]  
CHU T, 1987, LANCET, V1, P208
[5]   IMMUNOENZYMATIC LABELING OF MONOCLONAL-ANTIBODIES USING IMMUNE-COMPLEXES OF ALKALINE-PHOSPHATASE AND MONOCLONAL ANTI-ALKALINE PHOSPHATASE (APAAP COMPLEXES) [J].
CORDELL, JL ;
FALINI, B ;
ERBER, WN ;
GHOSH, AK ;
ABDULAZIZ, Z ;
MACDONALD, S ;
PULFORD, KAF ;
STEIN, H ;
MASON, DY .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1984, 32 (02) :219-229
[6]  
ESTERLY NB, 1985, J AM ACAD DERMATOL, V13, P481
[7]  
FALINI B, 1989, J IMMUNOL, V143, P2480
[8]  
Favara B E, 1987, Hematol Oncol Clin North Am, V1, P75
[9]   EXPRESSION OF THE GAMMA-DELTA-T-CELL RECEPTOR ON INTESTINAL CD8+ INTRAEPITHELIAL LYMPHOCYTES [J].
GOODMAN, T ;
LEFRANCOIS, L .
NATURE, 1988, 333 (6176) :855-858
[10]   POSSIBLE MECHANISM OF ACTION OF CD1A ANTIGENS [J].
HANAU, D ;
SCHMITT, DA ;
BIEBER, T ;
SCHMITT, D ;
CAZENAVE, JP .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (05) :503-505
123