GIGANTECIN - A NOVEL ANTIMITOTIC AND CYTOTOXIC ACETOGENIN, WITH NONADJACENT TETRAHYDROFURAN RINGS, FROM GONIOTHALAMUS-GIGANTEUS (ANNONACEAE)

被引：43
作者：
ALKOFAHI, A
RUPPRECHT, JK
LIU, YM
CHANG, CJ
SMITH, DL
MCLAUGHLIN, JL
机构：
[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, 47907, Indiana
来源：
EXPERIENTIA | 1990年 / 46卷 / 05期
关键词：
9; ASK; acetogenins; Annonaceae; antimitotic; brine shrimp; crown gall tumors; cytotoxic; Gigantecin; Goniothalamus giganteus; potato disc assay;
D O I：
10.1007/BF01954260
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK). © 1990 Birkhäuser Verlag.
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收藏
页码：539 / 541
页数：3
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