3 CONSISTENT PATTERNS OF RESPONSE TO SUBSTITUTED ACRIDINES IN A VARIETY OF BACTERIAL TESTER STRAINS USED FOR MUTAGENICITY TESTING

被引：19

作者：

FERGUSON, LR ^{[1
]}

DENNY, WA ^{[1
]}

MACPHEE, DG ^{[1
]}

机构：

[1] LA TROBE UNIV, DEPT MICROBIOL, BUNDOORA, VIC 3083, AUSTRALIA

来源：

MUTATION RESEARCH | 1985年 / 157卷 / 01期

关键词：

D O I：

10.1016/0165-1218(85)90046-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Substituted acridines (91) were tested for mutagenicity in 1 strain of Escherichia coli (TA78) and 4 strains of Salmonella typhimurium (TA90, TA1537, TA98 and TA100). Compounds fall into 3 groups: (i) inactive in all strains, (ii) active in TA78, TA90 and TA1537, or (iii) active in TA98 and often one or more of the other frameshift strains. Compounds of class iii were previously shown to differ from the others in causing excisible damage to DNA and in showing an enhanced mutagenic response when the plasmid pKM101 is present.

引用

页码：29 / 37

页数：9

共 17 条

[1]

Albert A., 1966, The Acridines. Their preparation, physical

[2] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].

AMES, BN ;

LEE, FD ;

DURSTON, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :782-786

[3]

AMES BN, 1974, 11 P INT CANC C FLOR

[4] DNA-BINDING AND GROWTH INHIBITORY PROPERTIES OF A SERIES OF 2,7-DI-ALKYL-SUBSTITUTED DERIVATIVES OF PROFLAVINE [J].

BAGULEY, BC ;

FERGUSON, LR ;

DENNY, WA .

CHEMICO-BIOLOGICAL INTERACTIONS, 1982, 42 (01) :97-105

[5] POTENTIAL ANTI-TUMOR AGENTS .36. QUANTITATIVE RELATIONSHIPS BETWEEN EXPERIMENTAL ANTI-TUMOR ACTIVITY, TOXICITY, AND STRUCTURE FOR THE GENERAL-CLASS OF 9-ANILINOACRIDINE ANTI-TUMOR AGENTS [J].

DENNY, WA ;

CAIN, BF ;

ATWELL, GJ ;

HANSCH, C ;

PANTHANANICKAL, A ;

LEO, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :276-315

[6] COMPARATIVE STUDIES OF MUTAGENIC, DNA-BINDING AND ANTILEUKEMIC PROPERTIES OF 9-ANILINOACRIDINE DERIVATIVES AND RELATED-COMPOUNDS [J].

FERGUSON, LR ;

MACPHEE, DG ;

BAGULEY, BC .

CHEMICO-BIOLOGICAL INTERACTIONS, 1983, 44 (1-2) :53-62

[7] FRAMESHIFT MUTAGENESIS BY 9-AMINOACRIDINE, ICR191, AMSA AND RELATED EXPERIMENTAL ANTI-TUMOR ACRIDINES IN RECA+ AND RECA1 STRAINS OF SALMONELLA-TYPHIMURIUM [J].

FERGUSON, LR ;

MACPHEE, DG .

MUTATION RESEARCH, 1983, 116 (3-4) :289-296

[8] FRAMESHIFT MUTAGENESIS BY ACRIDINES IN WILD-TYPE, UVRB AND POLA STRAINS OF SALMONELLA-TYPHIMURIUM WITH AND WITHOUT PLASMID PKM101 [J].

FERGUSON, LR ;

MACPHEE, DG .

MUTATION RESEARCH, 1984, 141 (02) :83-88

[9]

LEGHA SS, 1978, CANCER RES, V38, P3712

[10] REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST [J].

MARON, DM ;

AMES, BN .

MUTATION RESEARCH, 1983, 113 (3-4) :173-215

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