INTESTINAL PERMEABILITY IN MAN - EFFECTS OF ACUTE SYSTEMIC INFECTIONS

被引：4

作者：

ELIA, M

NORTHROPCLEWES, CA

LUNN, PG

GOREN, A

机构：

[1] Dunn Clinical Nutrition Centre, Cambridge, CB2 1QL

[2] Department of Gastroenterology, Yuksek Ihtisas Hospital, Ankara

来源：

CLINICAL NUTRITION | 1991年 / 10卷 / 02期

关键词：

D O I：

10.1016/0261-5614(91)90091-P

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Intestinal permeability was assessed (within 24-48 h of admission to hospital) in 7 patients suffering from acute infections, mainly pneumonia. The permeability test involved administering an oral solution containing a mixture of lactulose (10 g) mannitol (5 g and 0.5-mu-Ci) and Cr-51-EDTA (30-mu-Ci), and collecting urine samples before, and between 0-6, 6-12 and 12-24 h after dosing. The excretion of the markers was compared with the results obtained from 24 normal or control subjects and 15 patients with coeliac disease. None of the markers were excreted in significantly different amounts in the infected patients compared to the control subjects. In contrast, the coeliac patients excreted (0-6 h) four-fold more lactulose, three-fold more Cr-51-EDTA and two-fold less mannitol than the normal subjects. The ratio of lactulose:mannitol and Cr-51-EDTA:mannitol were therefore six- to eight-fold greater in the coeliac patients than in the normal subjects. The results confirm the sensitivity of the test for detecting the presence of an enteropathy but provide no evidence of a change in intestinal permeability in systemic infections studied under the stated conditions.

引用

页码：76 / 80

页数：5

共 42 条

[1]

Walker, Antigen handling by the gut, Archives of Disease in Childhood, 53, pp. 527-531, (1978)

[2]

Cunningham-Rundles, Failure of antigen exclusion, Food Allergy and Intolerance, pp. 223-236, (1987)

[3]

Galant, Biological and clinical significance of the gut as a barrier to penetration of macromolecules, Clinical Paediatrics, 15, pp. 731-734, (1976)

[4]

Walker, Role of the mucosal barrier in antigen handling by the gut, Food Allergy and Intolerance, pp. 209-222, (1987)

[5]

Paganelli, Levinsky, Solid phase radioimmunoassay for detection of circulating food protein antigens in human sera, Journal of Immunological Methods, 37, pp. 333-341, (1980)

[6]

Schloss, Worthem, The permeability of the gastrointestinal tract of infants to undigested proteins, American Journal of Diseases of Children, 11, pp. 342-360, (1985)

[7]

Walzer, Studies in absorption of undigested proteins in human beings. I. A simple direct method of studying the absorption of undigested proteins, Journal of Immunology, 14, pp. 143-149, (1927)

[8]

Lippard, Immunologic responses to ingestion of foods by normal and eczematous infants, American Journal of Diseases of Children, 57, pp. 524-540, (1939)

[9]

LeFerre, Ohro, Vanderhoff, Joel, Accumulation of latex in Peyer's patches and its subsequent appearance in villi and mesenteric lymph nodes, Proceedings of the Society for Experimental Biology and Medicine, 159, pp. 298-302, (1978)

[10]

Elia, Behrens, Northrop, Wraight, Neale, Evaluation of mannitol, lactulose and <sup>51</sup>Cr-labelled ethlenediaminetetra-acetate as markers of intestinal permeability in man, Clinical Science, 73, pp. 197-204, (1987)

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